System-level design space exploration (DSE), which is performed early in the design process, is of eminent importance to the design of complex multi-processor embedded system architectures. During system-level DSE, system parameters like, e.g., the number and type of processors, the type and size of memories, or the mapping of application tasks to architectural resources, are considered. Simulation-based DSE, in which different design instances are evaluated using system-level simulations, typically are computationally costly. Even using high-level simulations and efficient exploration algorithms, the simulation time to evaluate design points forms a real bottleneck in such DSE. Therefore, the vast design space that needs to be searched requires effective design space pruning techniques.This thesis presents different methods for iteratively reducing the number of simulations needed during system-level DSE.