This paper presents a framework for high-level power estimation of multiprocessor systems-on-chip (MPSoC) architectures on FPGA. The technique is based on abstract execution profiles, called event signatures. As a result, it is capable of achieving good evaluation performance, thereby making the technique highly useful in the context of early system-level design space exploration. We have integrated the power estimation technique in a system-level MPSoC synthesis framework. Using this framework, we have designed a range of different candidate MPSoC architectures and compared our power estimation results to those from real measurements on a Virtex-6 FPGA board.